Direct observation of markovian behavior of the mechanical unfolding of individual proteins.

Abstract

Single-molecule force-clamp spectroscopy is a valuable tool to analyze unfolding kinetics of proteins. Previous force-clamp spectroscopy experiments have demonstrated that the mechanical unfolding of ubiquitin deviates from the generally assumed Markovian behavior and involves the features of glassy dynamics. Here we use single molecule force-clamp… (More)
DOI: 10.1529/biophysj.107.128298

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