Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles.

@article{Miller2005DirectOD,
  title={Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles.},
  author={Kyle E. Miller and Jamin DeProto and Nancy Kaufmann and Bharatkumar Patel and April M. Duckworth and David L Van Vactor},
  journal={Current biology : CB},
  year={2005},
  volume={15 7},
  pages={684-9}
}
Axonal transport is required for the elaboration and maintenance of synaptic morphology and function. Liprin-alphas are scaffolding proteins important for synapse structure and electrophysiology. A reported interaction with Kinesin-3 (Kif1a) suggested Liprin-alpha may also be involved in axonal transport. Here, at the light and ultrastructural levels, we discover aberrant accumulations of synaptic vesicle markers (Synaptotagmin and Synaptobrevin-GFP) and clear-core vesicles along Drosophila… CONTINUE READING
55 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

Similar Papers

Loading similar papers…