Direct observation and characterization of DMPC/DHPC aggregates under conditions relevant for biological solution NMR.

@article{Dam2004DirectOA,
  title={Direct observation and characterization of DMPC/DHPC aggregates under conditions relevant for biological solution NMR.},
  author={Lorens van Dam and G{\"o}ran Karlsson and Katarina Edwards},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1664 2},
  pages={241-56}
}
We have used cryo-transmission electron microscopy (cryo-TEM) for inspection of aggregates formed by dimyristoylphosphatidylcholine (DMPC) and dihexanoylphosphatidylcholine (DHPC) in aqueous solution at total phospholipid concentrations cL < or = 5% and DMPC/DHPC ratios q < or = 4.0. In combination with ocular inspections, we are able to sketch out this part of phase-diagram at T = 14-80 degrees C. The temperature and the ratio q are the dominating variables for changing sample morphology… CONTINUE READING

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