Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella.

@article{Hayward1999DirectNA,
  title={Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella.},
  author={Richard D Hayward and Vassilis Koronakis},
  journal={The EMBO journal},
  year={1999},
  volume={18 18},
  pages={4926-34}
}
Salmonella causes severe gastroenteritis in humans, entering non-phagocytic cells to initiate intracellular replication. Bacterial engulfment occurs by macropinocytosis, which is dependent upon nucleation of host cell actin polymerization and condensation ('bundling') of actin filaments into cables. This is stimulated by contact-induced delivery of an array of bacterial effector proteins, including the four Sips (Salmonella invasion proteins). Here we show in vitro that SipC bundles actin… CONTINUE READING

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