Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

@article{Pardeshi2013DirectNT,
  title={Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting},
  author={Chandrakantsing V. Pardeshi and Veena Shailendra Belgamwar},
  journal={Expert Opinion on Drug Delivery},
  year={2013},
  volume={10},
  pages={957 - 972}
}
Introduction: The blood–brain barrier (BBB) represents a stringent barrier for delivery of neurotherapeutics in vivo. An attempt to overcome this barrier is represented by the direct transport of drugs from the nose to the brain along the olfactory and trigeminal nerve pathways. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain. An enormous range of neurotherapeutics, both macromolecules and low molecular weight drugs, can be delivered to… 
Progress in brain targeting drug delivery system by nasal route
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References

SHOWING 1-10 OF 113 REFERENCES
Nanoparticles for direct nose-to-brain delivery of drugs.
Intranasal delivery: An approach to bypass the blood brain barrier
TLDR
An attempt to overcome the barrier in vivo by using a novel, practical, simple and non-invasive approach i.e. intranasal delivery of therapeutic agents to the central nervous system (CNS).
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
Nasal Drug Delivery System-Factors Affecting and Applications
TLDR
The present article highlights the advantages, barriers, physicochemical factors and formulation related parameters affecting the nasal drug delivery and summarizes the applications of nasal route for delivery of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS.
CNS drug delivery systems: novel approaches.
TLDR
The objective of this article is to expansively review drug delivery systems for CNS by discussing the recent patents available.
Strategy for effective brain drug delivery.
  • M. I. Alam, S. Beg, M. Akbar
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2010
Intranasal delivery of biologics to the central nervous system.
The development and application of biological models for evaluation of direct nose-to-brain drug delivery systems
TLDR
In vitro and in vivo biological models showed surface modification had changed the distribution of nanoparticles within the epithelia and there was good agreement between particle losses from donor chamber, fluorescence microscopy images and stereology results that C-PS particles adhered to extracellular mucus to a greater extent compared to PS and P80-FCS-PS.
Intranasal delivery of cells to the brain.
Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway.
TLDR
The rapid appearance of rhNGF in the brain suggests that it may be transported by an extraneuronal route into the brain via intercellular clefts in the olfactory epithelium.
...
...