Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

  title={Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting},
  author={Chandrakantsing V. Pardeshi and Veena Shailendra Belgamwar},
  journal={Expert Opinion on Drug Delivery},
  pages={957 - 972}
Introduction: The blood–brain barrier (BBB) represents a stringent barrier for delivery of neurotherapeutics in vivo. An attempt to overcome this barrier is represented by the direct transport of drugs from the nose to the brain along the olfactory and trigeminal nerve pathways. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain. An enormous range of neurotherapeutics, both macromolecules and low molecular weight drugs, can be delivered to… 
Progress in brain targeting drug delivery system by nasal route
Nanotechnology-Mediated Nose-to-Brain Drug Delivery for Neurodegenerative Disorders
This chapter highlights the diagnosis and therapy of major neurodegenerative disorders (NDs) and developments in the nanotechnological areas for effectively delivering the neurotherapeutics to target the neuronal regions via direct nose-to-brain transport.
Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa
The state-of-the-art knowledge about the characteristics of the nasal and, in particular, the olfactory mucosa needed for a rational design of intranasal formulations and dosage forms are reviewed.
Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier
Mechanisms of nose-to-brain drug delivery are described and recent advances in this area are discussed with especial emphasis on nanotechnology-based approaches.
Quantitative analysis of drug delivery to the brain via nasal route.
Intranasal delivery bypasses the blood brain barrier and targets the CNS, reducing systemic exposure and thus systemic side effects and Avoids destruction in the gastrointestinal tract, hepatic “first pass” elimination and gut wall metabolism, allowing increased, reliable bioavailability.


Nanoparticles for direct nose-to-brain delivery of drugs.
Intranasal delivery: An approach to bypass the blood brain barrier
An attempt to overcome the barrier in vivo by using a novel, practical, simple and non-invasive approach i.e. intranasal delivery of therapeutic agents to the central nervous system (CNS).
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
Nasal Drug Delivery System-Factors Affecting and Applications
The present article highlights the advantages, barriers, physicochemical factors and formulation related parameters affecting the nasal drug delivery and summarizes the applications of nasal route for delivery of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS.
CNS drug delivery systems: novel approaches.
The objective of this article is to expansively review drug delivery systems for CNS by discussing the recent patents available.
Strategy for effective brain drug delivery.
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Intranasal delivery of biologics to the central nervous system.
The development and application of biological models for evaluation of direct nose-to-brain drug delivery systems
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Intranasal delivery of cells to the brain.
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The rapid appearance of rhNGF in the brain suggests that it may be transported by an extraneuronal route into the brain via intercellular clefts in the olfactory epithelium.