Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives.

Abstract

A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2-phenylthieno[2,3-d]pyrimidin-4-ylamino)-3-phenylpropanoic acid proved to have a significant activity towards liver, human breast and cervix carcinoma cell lines.

3 Figures and Tables

Cite this paper

@article{Sngaroff2009DirectMO, title={Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives.}, author={Katia Sn{\'e}garoff and Fr{\'e}d{\'e}ric Lassagne and Ghenia Bentabed-Ababsa and Ekhlass Nassar and Sidaty Cheikh Sid Ely and St{\'e}phanie Hesse and Enrico Perspicace and A{\"{i}cha Derdour and Florence Mongin}, journal={Organic & biomolecular chemistry}, year={2009}, volume={7 22}, pages={4782-8} }