Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone.

@article{Bagai2008DirectMT,
  title={Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone.},
  author={Ireena Bagai and Christopher Rensing and Ninian J. Blackburn and Megan M. McEvoy},
  journal={Biochemistry},
  year={2008},
  volume={47 44},
  pages={11408-14}
}
Transition metals require exquisite handling within cells to ensure that cells are not harmed by an excess of free metal species. In gram-negative bacteria, copper is required in only small amounts in the periplasm, not in the cytoplasm, so a key aspect of protection under excess metal conditions is to export copper from the periplasm. Additional protection could be conferred by a periplasmic chaperone to limit the free metal species prior to export. Using isothermal titration calorimetry, we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…