Direct measurement of single synthetic vertebrate thick filament elasticity using nanofabricated cantilevers.

@article{Dunaway2002DirectMO,
  title={Direct measurement of single synthetic vertebrate thick filament elasticity using nanofabricated cantilevers.},
  author={Dwayne L Dunaway and Mark Fauver and Gerald H. Pollack},
  journal={Biophysical journal},
  year={2002},
  volume={82 6},
  pages={3128-33}
}
Thick filaments are generally thought to be effectively inextensible. Here we use novel nanofabricated cantilevers to carry out the first direct force-elongation measurements on single vertebrate thick filaments. Cantilevers are ideal for these experiments: force ranges are from pico- to micronewtons, specimens can be visualized during the experiment, and attachment surfaces are in the same plane as the filament. Synthetic thick filaments from rabbit myosin were suspended between two… CONTINUE READING

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