Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

@article{Chary1989DirectMO,
  title={Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.},
  author={S R Chary and Rakesh K. Jain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 14},
  pages={5385-9}
}
Macromolecular transport through the interstitial space of a tissue occurs by convection and diffusion. The convective component of transport results from interstitial fluid flow. There have been no direct measurements of the magnitude or direction of interstitial fluid flow in tissues to date. Using fluorescence recovery after photobleaching, we have measured interstitial fluid velocities and the diffusion coefficient of bovine serum albumin in normal and neoplastic tissues grown in a thin… CONTINUE READING