Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.

Abstract

Cells control their own death through a program termed apoptosis, which is indispensable for development and homeostasis in all metazoans. Lysosomal cysteine proteases are not normally thought of as participating in apoptosis; however, recent reports have shown that the cathepsin proteases can be released from the lysosome during apoptosis, where they can… (More)
DOI: 10.1016/j.chembiol.2009.07.011

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@article{Pratt2009DirectMO, title={Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.}, author={Matthew R Pratt and Matthew D. Sekedat and Kyle Chiang and Tom W Muir}, journal={Chemistry & biology}, year={2009}, volume={16 9}, pages={1001-12} }