Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism.

@article{Shiizaki2006DirectMI,
  title={Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism.},
  author={Kazuhiro Shiizaki and Ikuji Hatamura and Shigeo Negi and Toshifumi Sakaguchi and Fumie Saji and Ken Kunimoto and Mari Okamoto and Ikuo Imazeki and Yasuteru Muragaki and Tadao Akizawa},
  journal={Kidney international},
  year={2006},
  volume={70 3},
  pages={486-95}
}
Direct maxacalcitol (OCT) injection into a parathyroid gland (PTG) ameliorates several important etiologic factors of resistance to medical treatments for secondary hyperparathyroidism (s-HPT): the upregulations of vitamin D receptor (VDR) and Ca-sensing receptor (CaSR) in PTGs and the regression of PTG hyperplasia by the induction of apoptosis. In this study, we evaluated the bone histomorphology on the basis of maintaining these effects in advanced s-HPT. Five/six nephrectomized Sprague… CONTINUE READING
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