Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density.

@article{Wilhelm2012DirectMR,
  title={Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density.},
  author={Michael J. Wilhelm and Henry H. Ong and Suzanne L. Wehrli and Cheng Li and Ping-Huei Tsai and David B. Hackney and Felix W. Wehrli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 24},
  pages={9605-10}
}
Magnetic resonance imaging has previously demonstrated its potential for indirectly mapping myelin density, either by relaxometric detection of myelin water or magnetization transfer. Here, we investigated whether myelin can be detected and possibly quantified directly. We identified the spectrum of myelin in the spinal cord in situ as well as in myelin lipids extracted via a sucrose gradient method, and investigated its spectral properties. High-resolution solution NMR spectroscopy showed the… CONTINUE READING
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Does MD (2011) Origins of the ultrashort-T2 1H NMR signals in myelinated nerve: A direct measure of myelin content

  • RA Horch, JC Gore
  • Magn Reson Med
  • 2011

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