Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium.

@article{Gervelas2007DirectLD,
  title={Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium.},
  author={Claudia Gervelas and A-L S{\'e}randour and Sebastian Geiger and G{\'e}rard Grillon and Paul W. Fritsch and C Taulelle and B{\'e}atrice Le Gall and Henri C Benech and J-R Deverre and Elias Fattal and Nicolas Tsapis},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={118 1},
  pages={
          78-86
        }
}
DTPA, an actinide chelating agent, has demonstrated its ability to complex plutonium (Pu) and to facilitate its urinary excretion after internal contamination. This process, known as decorporation is crucial to diminish the burden of Pu in the body. The ability to deliver a chelating agent directly to the alveolar region may increase its local concentration as compared to systemic delivery and therefore increase the extent of decorporation. Second, inhalation offers the potential for needle… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Dexamethasone palmitate large porous particles: A controlled release formulation for lung delivery of corticosteroids.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Modélisation de la décorporation du Pu/am par le dtpa

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…