Direct linkage of epidermal growth factor to its receptor

  title={Direct linkage of epidermal growth factor to its receptor},
  author={Peter S. Linsley and Cindy Blifeld and M M Wrann and Catherine F Fox},
EPIDERMAL GROWTH FACTOR (EGF), a potent polypeptide mitogen, has been studied intensively by those concerned with the molecular events leading to cell proliferation1–4. The initial, reversible interaction of EGF with a specific cell surface receptor and the subsequent internalisation and degradation of EGF, and by inference the EGF–receptor complex, are… CONTINUE READING