Direct link between RACK1 function and localization at the ribosome in vivo.

@article{Coyle2009DirectLB,
  title={Direct link between RACK1 function and localization at the ribosome in vivo.},
  author={Scott M. Coyle and Wendy V Gilbert and Jennifer A. Doudna},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 6},
  pages={
          1626-34
        }
}
The receptor for activated C-kinase (RACK1), a conserved protein implicated in numerous signaling pathways, is a stoichiometric component of eukaryotic ribosomes located on the head of the 40S ribosomal subunit. To test the hypothesis that ribosome association is central to the function of RACK1 in vivo, we determined the 2.1-A crystal structure of RACK1 from Saccharomyces cerevisiae (Asc1p) and used it to design eight mutant versions of RACK1 to assess roles in ribosome binding and in vivo… CONTINUE READING

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