Direct labelling of myocardial β1-adrenoceptors

@article{Kaumann2004DirectLO,
  title={Direct labelling of myocardial $\beta$1-adrenoceptors},
  author={Alberto Julio Kaumann and Horst Lemoine},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={331},
  pages={27-39}
}
SummaryA radioligand that selectively labels β1-adrenoceptors, 3H-(−)-bisoprolol (3H-BIS), is introduced. The binding properties of 3H-BIS to membrane particles of kitten heart are compared with the blocking properties of (−)-bisoprolol against stimulant effects of (−)-adrenaline and (−)-noradrenaline in heart preparations of kitten and guinea pig. 1.On kitten heart tissues (-)-bisoprolol antagonized the positive chronotropic and inotropic effects of catecholamines competitively. The effects… Expand

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SummaryA radioligand that selectively labels β2-adrenoceptors, 3H-ICI 118,551 (3H-ICI), is introduced. Experiments were performed on guinea-pig tissues. The binding characteristics of 3H-ICI on lungExpand
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