Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.

@article{Hama1999DirectIO,
  title={Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.},
  author={Hiroko Hama and Elisabeth A. Schnieders and J. Thorner and Jon Y Takemoto and Daryll B Dewald},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 48},
  pages={34294-300}
}
The SEC14 gene encodes an essential phosphatidylinositol (PtdIns) transfer protein required for formation of Golgi-derived secretory vesicles in yeast. Suppressor mutations that rescue temperature-sensitive sec14 mutants provide an approach for determining the role of Sec14p in secretion. One suppressor, sac1-22, causes accumulation of PtdIns(4)P. SAC1 encodes a phosphatase that can hydrolyze PtdIns(4)P and certain other phosphoinositides. These findings suggest that PtdIns(4)P is limiting in… CONTINUE READING
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