Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.

@article{Mackey2013DirectIA,
  title={Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.},
  author={Scott Mackey and Yu hong Jing and Joseph Flores and Katie Dinelle and Doris J. Doudet},
  journal={Experimental neurology},
  year={2013},
  volume={247},
  pages={19-24}
}
Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistently produced important features of the disease. In this study, a range of lactacystin doses (0.5, 1, 2, 10 and 20 μg) were injected into the right substantia nigra in rats to determine the ideal dose required to produce a robust and specific… CONTINUE READING

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