Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function.

  title={Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function.},
  author={Delin Chen and Muyang Li and Jianyuan Luo and Wei Gu},
  journal={The Journal of biological chemistry},
  volume={278 16},
The p53 tumor suppressor is maintained at low levels in normal cells by Mdm2-mediated degradation and strongly stabilized in response to various types of stress including hypoxia. Although hypoxia-inducible factor 1 alpha (HIF-1 alpha) has been implicated to be involved in p53 stabilization, the precise mechanism by which HIF-1 alpha regulates p53-mediated function remains unknown. Here, we found that HIF-1 alpha directly binds Mdm2 both in vitro and in vivo; in contrast, p53 fails to directly… CONTINUE READING

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