Direct interactions between Epstein-Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation.

@article{Peng2004DirectIB,
  title={Direct interactions between Epstein-Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation.},
  author={Chih-wen Peng and Yong Xue and Bo Zhao and Eric A Johannsen and Elliott Kieff and Shizuko Harada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 4},
  pages={1033-8}
}
The Epstein-Barr virus nuclear leader protein LP (EBNALP) and EBNA2 are expressed first in lymphocyte infection, coordinately regulate cell and viral gene transcription, and are critical for lymphocyte outgrowth into lymphoblastoid cell lines (LCLs). We have now found that EBNALP readily associated with EBNA2 or with the EBNA2 C-terminal acidic activation domain (E2AD) when both components were expressed by bacteria. In lymphoblasts, EBNALP and EBNA2 did not stably associate. However, EBNALP… CONTINUE READING

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