Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR.

@article{Thelin2007DirectIW,
  title={Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR.},
  author={William R. Thelin and Yun Chen and Martina Gentzsch and Silvia M. Kreda and Jennifer Leigh Sallee and Cameron O. Scarlett and Christoph H. Borchers and Ken Jacobson and M Jackson Stutts and Sharon L. Milgram},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 2},
  pages={364-74}
}
The role of the cystic fibrosis transmembrane conductance regulator (CFTR) as a cAMP-dependent chloride channel on the apical membrane of epithelia is well established. However, the processes by which CFTR is regulated on the cell surface are not clear. Here we report the identification of a protein-protein interaction between CFTR and the cytoskeletal filamin proteins. Using proteomic approaches, we identified filamins as proteins that associate with the extreme CFTR N terminus. Furthermore… CONTINUE READING

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