Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice.

@article{Kaul2003DirectIW,
  title={Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice.},
  author={Ruchika Kaul and Sujoy Mukherjee and Farid Ahmed and Manoj Kumar Bhat and Rishiraj Chhipa and Sanjeev Galande and Samit Chattopadhyay},
  journal={International journal of cancer},
  year={2003},
  volume={103 5},
  pages={606-15}
}
The tumor-suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor-suppressor activity by either causing cell-cycle arrest (G(1)/S or G(2)/M) or inducing cells to undergo apoptosis. This function of wild-type p53 as "guardian of the genome" is presumably achieved by forming molecular complexes with different DNA targets as well as by interacting with a number of cellular proteins, e.g., Mdm2, Gadd45, p21, 14-3-3sigma, Bax and Apaf-1… CONTINUE READING