Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

@article{Lupu1990DirectIO,
  title={Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.},
  author={Ana Ramona Lupu and R Colomer and Gerhard Zugmaier and Jay C. Sarup and Marian W Shepard and Dennis Slamon and Marc E. Lippman},
  journal={Science},
  year={1990},
  volume={249 4976},
  pages={1552-5}
}
The erbB2 oncogene encodes a 185-kilodalton transmembrane protein whose sequence is similar to the epidermal growth factor receptor (EGFR). A 30-kilodalton factor (gp30) secreted from MDA-MB-231 human breast cancer cells was shown to be a ligand for p185erbB2. An antibody to EGFR abolished the tyrosine phosphorylation induced by EGF and transforming growth factor-alpha (TGF-alpha) but only partially blocked that produced by gp30 in SK-BR-3 breast cancer cells. In two cell lines that overexpress… CONTINUE READING

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