Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene.

@article{Barbara1998DirectIO,
  title={Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-M{\"u}llerian hormone gene.},
  author={Pascal de Santa Barbara and Nathalie Bonneaud and Brigitte Boizet and Marion Desclozeaux and Brigitte Moniot and P Sudbeck and Gerd Scherer and Francis Poulat and Philippe Berta},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 11},
  pages={6653-65}
}
For proper male sexual differentiation, anti-Müllerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Müllerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic factor 1 (SF-1), a member of the orphan nuclear receptor family, located in the AMH proximal promoter has recently been characterized and demonstrated as being essential for AMH… CONTINUE READING
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