Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.

@article{Quaedackers2007DirectIB,
  title={Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.},
  author={Monique E Quaedackers and Christina E van den Brink and Paul T. van der Saag and Leon G.J Tertoolen},
  journal={Molecular and cellular endocrinology},
  year={2007},
  volume={273 1-2},
  pages={42-50}
}
Inhibition of NF-kappaB transcriptional activity by steroid receptors is the basis for the antiinflammatory actions of steroid hormones and the molecular mechanism underlying this cross-talk is thought to involve direct protein-protein interactions. In this study, we show that estrogen receptor (ER)alpha and NF-kappaB interact in vivo by using fluorescence resonance energy transfer (FRET) and co-immunoprecipitation. U2-OS cells were used to study direct interactions between fluorescent fusion… CONTINUE READING
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