Direct interaction between crystalline silica and DNA - a proposed model for silica carcinogenesis.

@article{Daniel1995DirectIB,
  title={Direct interaction between crystalline silica and DNA - a proposed model for silica carcinogenesis.},
  author={Lambert N. Daniel and Yue Mao and A. Olufemi Williams and Umberto Saffiotti},
  journal={Scandinavian journal of work, environment & health},
  year={1995},
  volume={21 Suppl 2},
  pages={22-6}
}
Crystalline silica in aqueous buffer produced oxygen radicals that mediated in vitro DNA (deoxyribonucleic acid) strand breakage. The oxidized DNA base, thymine glycol, was also produced. The hydroxyl radical, responsible for most DNA damage, has a reaction distance of about 15 Angstroms, requiring close contact of silica with DNA. Fourier transform infrared spectroscopy of incubations of quartz particles with DNA showed distinct alterations in both DNA and quartz spectra and therefore… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
10 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…