Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.

@article{Wei2012DirectIB,
  title={Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.},
  author={Chun-yu Wei and Wen-Hung Chung and Hsiao-Wen Huang and Yuan-Tsong Chen and Shuen-Iu Hung},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 6},
  pages={1562-9.e5}
}
BACKGROUND Increasing studies have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however, the underlying molecular mechanism remains unclear. OBJECTIVE We adopted the HLA-B∗1502 genetic predisposition to carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) as a model to study the pathologic role of HLA in delayed-type drug hypersensitivity. METHODS We in vitro expanded CBZ-specific cytotoxic T lymphocytes (CTLs… CONTINUE READING

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