Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.

@article{Liu2006DirectIA,
  title={Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.},
  author={Qinghang Liu and Benjamin J. Wilkins and Yong Jae Lee and Hidenori Ichijo and Jeffery D Molkentin},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 10},
  pages={3785-97}
}
The calcium-calmodulin-activated protein phosphatase calcineurin functions as a key mediator of diverse biologic processes, including differentiation, apoptosis, growth, and adaptive responses, in part through dephosphorylation and activation of nuclear factor of activated T-cell (NFAT) transcription factors. Apoptosis signal-regulating kinase 1 (ASK1) is an upstream component of the mitogen-activated protein kinases that serves as a pivotal regulator of cytokine-, oxidative-, and stress… CONTINUE READING

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