Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis

@inproceedings{Turnbull2012DirectIO,
  title={Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis},
  author={Arran Turnbull and Robert R. Kitchen and Alexey Larionov and Lorna Renshaw and J Michael J Dixon and Andrew H Sims},
  booktitle={BMC Medical Genomics},
  year={2012}
}
Affymetrix GeneChips and Illumina BeadArrays are the most widely used commercial single channel gene expression microarrays. Public data repositories are an extremely valuable resource, providing array-derived gene expression measurements from many thousands of experiments. Unfortunately many of these studies are underpowered and it is desirable to improve power by combining data from more than one study; we sought to determine whether platform-specific bias precludes direct integration of… CONTINUE READING

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