Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.

  title={Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.},
  author={Gwendolyn W. Louis and Gina M Leinninger and Christopher J Rhodes and Martin G Myers},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 34},
Leptin, the adipose-derived hormonal signal of body energy stores, acts via the leptin receptor (LepRb) on neurons in multiple brain regions. We previously identified LepRb neurons in the lateral hypothalamic area (LHA), which are distinct from neighboring leptin-regulated melanin-concentrating hormone (MCH)- or orexin (OX)-expressing cells. Neither the direct synaptic targets of LHA LepRb neurons nor their potential role in the regulation of other LHA neurons has been determined, however. We… CONTINUE READING


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