Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.

@article{Ono2012DirectIO,
  title={Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.},
  author={Yoshihiro Ono and Tetsu Hayashida and Ayano Konagai and Hiroshi Okazaki and Kazuhiro Miyao and Shigeyuki Kawachi and Masatomo Tanabe and Masayoshi Shinoda and Hiromitsu Jinno and Hiroshi Hasegawa and Masaki Kitajima and Yuukou Kitagawa},
  journal={Cancer science},
  year={2012},
  volume={103 2},
  pages={
          317-24
        }
}
Transforming growth factor-β (TGF-β) is involved in the regulation of cell proliferation, differentiation, and apoptosis and is associated with epithelial-mesenchymal transition (EMT). Inhibition of the TGF-β pathway is an attractive strategy for the treatment of cancer. We recently screened for novel TGF-β inhibitors among commercially available drugs and identified protein-bound polysaccharide (PSK) as a strong inhibitor of the TGF-β-induced reporter activity of 3TP-lux, a TGF-β1-responsive… CONTINUE READING
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