Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone.

@article{Sayeed2009DirectIO,
  title={Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone.},
  author={Iqbal Sayeed and Suhel Parvez and Bushra Wali and Detlef Siemen and Donald G. Stein},
  journal={Brain research},
  year={2009},
  volume={1263},
  pages={165-73}
}
We previously demonstrated that the progesterone (PROG) metabolite allopregnanolone (AP) is more potent than PROG in the treatment of traumatic brain injury (TBI) and stroke, but the mechanisms for this differential effect are little understood. The mitochondrial permeability transition pore (mtPTP) appears to be a key player in the intrinsic pathway of apoptosis-induced loss of neurons. Its activation is accompanied by the release of cytochrome c (cyt c) from the intermembrane gap and… CONTINUE READING