Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.

@article{Karkare2014DirectIO,
  title={Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.},
  author={Swagata Karkare and Rishi Raj Chhipa and Jane A. Anderson and Xiaona Liu and Heather Henry and Anjelika Gasilina and Nicholas Nassar and Jayeeta Ghosh and Jason Clark and Ashish Kumar and Giovanni M. Pauletti and Pradip Kumar Ghosh and Biplab Dasgupta},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 1},
  pages={199-212}
}
PURPOSE Classical pharmacology allows the use and development of conventional phytomedicine faster and more economically than conventional drugs. This approach should be tested for their efficacy in terms of complementarity and disease control. The purpose of this study was to determine the molecular mechanisms by which nimbolide, a triterpenoid found in the well-known medicinal plant Azadirachta indica, controls glioblastoma growth. EXPERIMENTAL DESIGN Using in vitro signaling, anchorage… CONTINUE READING
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