Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

@inproceedings{Marini2013DirectIO,
  title={Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer},
  author={Cecilia Marini and Barbara Salani and Michela Massollo and Adriana Agnese Amaro and Alessia Isabella Esposito and Anna Maria Orengo and Selene Capitanio and Laura Emionite and Mattia Riondato and Gianluca Bottoni and Cinzia Massara and Simona Boccardo and Marina Fabbi and Cristina Campi and Silvia Ravera and Giovanna Angelini and Silvia Morbelli and Michele Cilli and Renzo Cordera and Mauro Truini and Davide Maggi and Ulrich Pfeffer and Gianmario Sambuceti},
  booktitle={Cell cycle},
  year={2013}
}
Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present study, we demonstrate that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative breast cancer (MDA-MB-231). The inhibition is selective for these isoforms, as documented by experiments with purified HK I and II as well as with cell lysates. Measurements of (18)F-fluoro… CONTINUE READING
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