Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture.

@article{Osborne1979DirectIO,
  title={Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture.},
  author={Charles Osborne and Marie E. Monaco and C Ronald Kahn and Karen Huff and Diane Bronzert and Marc E. Lippman},
  journal={Cancer research},
  year={1979},
  volume={39 7 Pt 1},
  pages={2422-8}
}
We have examined the interaction of dexamethasone with the ZR75-1 human breast cancer cell line to determine if glucocorticoids might directly inhibit growth of breast cancer cells. Growth of these cells in serum-free medium was stimulated significantly by physiological concentrations of insulin (0.1 to 1.0 nM). Pharmacological concentrations of dexamethasone (10 nM) reduced cell number below that found in controls and nearly abolished the effect of insulin after several days in culture… CONTINUE READING

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