Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine

@article{Ozaki1990DirectIO,
  title={Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine},
  author={Hiroshi Ozaki and Hideo Kasai and M Hori and Koichi Sato and Hiroaki Ishihara and Hideaki Karaki},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1990},
  volume={341},
  pages={262-267}
}
The mechanism of the inhibitory effect of caffeine on smooth muscle contraction was examined using chicken gizzard. Caffeine (0.1–5 mmol/l) inhibited the KCl-induced contraction of the muscle with an IC50 of 1.1 mmol/l. Forskolin (0.01–10 μmol/l) also inhibited KCl-induced contraction. The inhibitory effect of caffeine was potentiated by a low concentration of forskolin (0.3 μmol/l) and the inhibitory effect of forskolin was potentiated by a low concentration of caffeine (0.1 mmol/l). Although… CONTINUE READING

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