Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein

@article{Liu2001DirectIO,
  title={Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein},
  author={Wei-min Liu and Ileana Quinto and Xueni Chen and Camillo Palmieri and Ronald L Rabin and Owen M. Schwartz and David L. Nelson and Giuseppe Scala},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={939-946}
}
Bruton's tyrosine kinase (Btk) is required for human and mouse B cell development. Btk deficiency causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Unlike Src proteins, Btk lacks a negative regulatory domain at the COOH terminus and may rely on cytoplasmic Btk-binding proteins to regulates its kinase activity by trans-inhibitor mechanisms. Consistent with this possibility, IBtk, which we identified as an inhibitor of Btk, bound to the PH domain of Btk… CONTINUE READING

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