Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.

@article{Hargreaves1996DirectIO,
  title={Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.},
  author={Andy C Hargreaves and Martin J. Gunthorpe and Colin W Taylor and Sarah C. R. Lummis},
  journal={Molecular pharmacology},
  year={1996},
  volume={50 5},
  pages={1284-94}
}
Homopentameric complexes of either the A or As subunit of the 5-hydroxytryptamine3 receptor form Ca(2+)-permeable channels that can be activated by the selective agonist 1-(m-chlorophenyl)-biguanide (mCPBG). In both N1E-115 neuroblastoma cells and human embryonic kidney 293 cells stably expressing the 5-HT3 receptor As subunit, (+)-verapamil, (-)-verapamil, diltiazem, and nimodipine caused reversible and concentration-dependent (IC50 = 2.5-6.5 microM) inhibition of the increases in cytosolic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…