Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function.

@article{Donahue2001DirectIO,
  title={Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function.},
  author={Ronald J Donahue and Marjaneh Razmara and Jan B. Hoek and Thomas B Knudsen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 3},
  pages={635-44}
}
Mitochondrial localization of p53 has been observed in several cell systems, but an understanding of its organelle-based physiological activity remains incomplete. The purpose of the present study was to investigate the mitochondrial DNA genomic response to dominant-negative p53 mutant miniprotein (p53DD) fused to a mitochondrial import signal. Constructs were generated to express mitochondrial targeted enhanced green fluorescent protein (mEGFP) or dominant-negative mutant p53 miniprotein… CONTINUE READING