Direct induction of tissue factor synthesis by endotoxin in human macrophages from diverse anatomical sites.

@article{Semeraro1983DirectIO,
  title={Direct induction of tissue factor synthesis by endotoxin in human macrophages from diverse anatomical sites.},
  author={Nicola Semeraro and Andrea Biondi and Roberto Lorenzet and Daniela Locati and Alberto Mantovani and Maria Benedetta Donati},
  journal={Immunology},
  year={1983},
  volume={50 4},
  pages={529-35}
}
On exposure to endotoxin and other stimuli, human peripheral-blood mononuclear cells generate a potent procoagulant activity (PCA), identified as tissue factor. Although it is now recognized that the monocytes are the source of PCA, the question whether these cells per se are capable of procoagulant response to endotoxin or require lymphocyte collaboration remains unsettled. We have investigated the capacity of highly purified human macrophages from diverse anatomical sites to generate PCA… CONTINUE READING

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