Direct in vivo cellular reprogramming involves transition through discrete, non-pluripotent steps.

@article{Richard2011DirectIV,
  title={Direct in vivo cellular reprogramming involves transition through discrete, non-pluripotent steps.},
  author={Jai Prakash Richard and Steven Zuryn and Nadine Fischer and Valeria Pavet and Nad{\`e}ge Vaucamps and Sophie Jarriault},
  journal={Development},
  year={2011},
  volume={138 8},
  pages={1483-92}
}
Cells can change identity during normal development, in response to tissue damage or defined artificial treatments, or during disease processes such as cancer. Strikingly, not only the reprogramming of tissue cells to an embryonic stem cell-like state, but also the direct conversion from one cell type to another have been described. Direct cell type conversion could represent an alternative strategy for cellular therapies. However, little is known about the actual cellular steps undertaken by a… CONTINUE READING
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