Direct in vivo VH to JH rearrangement violating the 12/23 rule

  title={Direct in vivo VH to JH rearrangement violating the 12/23 rule},
  author={Sergei B. Koralov and Tatiana I. Novobrantseva and Konrad Hochedlinger and Rudolf Jaenisch and K. Rajewsky},
  journal={The Journal of Experimental Medicine},
  pages={341 - 348}
V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23 rule to ensure the correct assembly of the variable region gene segments. Here, we report characterization of an in vivo model that allowed us to study recombination violating the 12/23 rule, namely a mouse strain lacking canonical D elements in its IgH locus. We demonstrate that VH to JH joining can support the generation of all B cell subsets. However, the process is inefficient in that B cells and antibodies… CONTINUE READING
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