Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.


Mining modern genomics for cancer therapies is predicated on weeding out "bystander" alterations (nonconsequential mutations) and identifying "driver" mutations responsible for tumorigenesis and/or metastasis. We used a direct in vivo RNA interference (RNAi) strategy to screen for genes that upon repression predispose mice to squamous cell carcinomas (SCCs… (More)
DOI: 10.1126/science.1248627


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