Direct identification of PTEN phosphorylation sites.

  title={Direct identification of PTEN phosphorylation sites.},
  author={Susan J Miller and David Y. S. Lou and David C. Seldin and William S. Lane and Benjamin G Neel},
  journal={FEBS letters},
  volume={528 1-3},
The PTEN tumor suppressor gene encodes a phosphatidylinositol 3'-phosphatase that is inactivated in a high percentage of human tumors, particularly glioblastoma, melanoma, and prostate and endometrial carcinoma. Previous studies showed that PTEN is a seryl phosphoprotein and a substrate of protein kinase CK2 (CK2). However, the sites in PTEN that are phosphorylated in vivo have not been identified directly, nor has the effect of phosphorylation on PTEN catalytic activity been reported. We used… CONTINUE READING

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