Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues.

Abstract

Human engineered heart tissues have potential to revolutionize cardiac development research, drug-testing, and treatment of heart disease; however, implementation is limited by the need to use pre-differentiated cardiomyocytes (CMs). Here we show that by providing a 3D poly(ethylene glycol)-fibrinogen hydrogel microenvironment, we can directly differentiate… (More)
DOI: 10.1016/j.biomaterials.2015.12.011

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Cite this paper

@article{Kerscher2016DirectHE, title={Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues.}, author={Petra Kerscher and Irene C. Turnbull and Alexander J Hodge and Joonyul Kim and Dror Seliktar and Christopher J Easley and Kevin D. Costa and Elizabeth A Lipke}, journal={Biomaterials}, year={2016}, volume={83}, pages={383-95} }