Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

@article{Schier1992DirectHI,
  title={Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene},
  author={Alexander F Schier and W. J. Gehring},
  journal={Nature},
  year={1992},
  volume={356},
  pages={804-807}
}
A MAJOR problem in the elucidation of the molecular mechanisms governing development is the distinction between direct and indirect regulatory interactions among developmental control genes1–5. In vivo studies have indicated that the Drosophila segmentation genefushi tarazu (ftz) directly or indirectly autoregulates its expression6. Here we describe a generally applicable experimental approach which establishes a direct in vivo interaction of the homeodomain protein ftz with the ftz cis… CONTINUE READING

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