Direct high-performance liquid chromatographic separation of peptide enantiomers: study on chiral recognition by systematic evaluation of the influence of structural features of the chiral selectors on enantioselectivity.

@article{Czerwenka2002DirectHL,
  title={Direct high-performance liquid chromatographic separation of peptide enantiomers: study on chiral recognition by systematic evaluation of the influence of structural features of the chiral selectors on enantioselectivity.},
  author={Christoph Czerwenka and Michael L{\"a}mmerhofer and Norbert M Maier and Kari Rissanen and Wolfgang Lindner},
  journal={Analytical chemistry},
  year={2002},
  volume={74 21},
  pages={5658-66}
}
All-R/all-S enantiomers of oligoalanines (Ala(n), n = 1-10) with N-terminal protection group have been separated by HPLC on chiral stationary phases based on various cinchona alkaloid selectors. Structure-enantioselectivity relationships derived by extensive selector structure optimization provided insights into binding mechanisms and chiral recognition… CONTINUE READING