Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils.

@article{Stefanovic2005DirectHE,
  title={Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils.},
  author={Lela Stefanovic and David A. Brenner and Branko Stefanovic},
  journal={Experimental biology and medicine},
  year={2005},
  volume={230 8},
  pages={
          573-86
        }
}
KC is a mouse homolog of human chemokine gro-alpha (CXCL1), expression of which is increased in liver diseases. We show that activated, but not quiescent, hepatic stellate cells (HSCs) express KC. Hepatic stellate cells constitutively express the KC receptor, CXCR2. Addition of recombinant KC to HSCs undergoing activation in culture increases secretion and processing of Type I collagen. Overexpression of endogenous KC in the mouse liver could be achieved by an intraperitoneal injection of CCl(4… CONTINUE READING
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