Direct gene transfer for the understanding and treatment of human disease.

@article{Plautz1994DirectGT,
  title={Direct gene transfer for the understanding and treatment of human disease.},
  author={Gregory E. Plautz and Elizabeth G. Nabel and Bernard A Fox and Zhiqiang Yang and M. Jaffe and David Gordon and Alfred E. Chang and Gary J. Nabel},
  journal={Annals of the New York Academy of Sciences},
  year={1994},
  volume={716},
  pages={144-53}
}
Direct gene transfer has been used to develop molecular genetic interventions for acquired diseases in several animal models. Through the use of intravascular catheters or anatomically localized injection of DNA liposome complexes, specific tissues can be transduced with recombinant genes. Several promising applications of this method for the study of vascular biology have been demonstrated by direct gene transfer into arteries in vivo. Delivery, via catheter, of genes that modulate the… CONTINUE READING