Direct experimental occlusion of the distal middle cerebral artery induces high reproducibility of brain ischemia in mice.

@article{Kuraoka2009DirectEO,
  title={Direct experimental occlusion of the distal middle cerebral artery induces high reproducibility of brain ischemia in mice.},
  author={Mutsuki Kuraoka and T Furuta and T Matsuwaki and Tsutomu Omatsu and Yoshiyuki Ishii and Shigeru Kyuwa and Yasuhiro Yoshikawa},
  journal={Experimental animals},
  year={2009},
  volume={58 1},
  pages={19-29}
}
Several investigators have used murine models to investigate the pathophysiology of brain ischemia. The focal ischemic model is a closer approximation to human stroke which includes a necrotic core, penumbra, and undamaged tissue. Occlusion of a unilateral artery, especially the middle cerebral artery (MCA), is performed in this model, but collateral circulation often induces variation of ischemic lesions both qualitatively and quantitatively. It is likely that the more proximal the artery… CONTINUE READING